(INVITED)Nanocoated fiber label-free biosensing for perfluorooctanoic acid detection by lossy mode resonance

The determination of per- and polyfluoroalkyl substances (PFAS) in environmental samples, such as drinking waters, requires the design high performing versatile sensing strategies. Label-free biosensing platforms based on specialty fiber optics are a valid option to face this challenge. Among them, lossy mode resonance (LMR) optic biosensors showing remarkable performance terms detection limit, selectivity, reproducibility. small molecules, perfluorooctanoic acid (PFOA), can be achieved with help well-designed biological recognition layers. In study, potentialities label-free LMR-assisted optical platform nanocoated fibers investigated. Delipidated human serum albumin (hSA) was used layer for PFOA aqueous solution. Different functionalization protocols covalent immobilization hSA were tested. conformational changes related formation hSA/PFOA complex followed via monitoring LMR spectral shift, trend that modeled Langmuir adsorption isotherm. These results confirmed potentiality LMR-based PFOA, synthetic samples.